Cobicistat

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Chemical Structure| 1004316-88-4 同义名 : 考西司他 ;GS-9350
CAS号 : 1004316-88-4
货号 : A421342
分子式 : C40H53N7O5S2
纯度 : 99%+
分子量 : 776.02
MDL号 : MFCD18251449
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Cobicistat is a potent and selective inhibitor of CYP3A with IC50 of 30-285 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.29mL

0.26mL

0.13mL

6.44mL

1.29mL

0.64mL

12.89mL

2.58mL

1.29mL
参考文献

[1]Pozniak A, Markowitz M, et al. Switching to coformulated elvitegravir, cobicistat, emtricitabine, and tenofovir versus continuation of non-nucleoside reverse transcriptase inhibitor with emtricitabine and tenofovir in virologically suppressed adults with HIV (STRATEGY-NNRTI): 48 week results of a randomised, open-label, phase 3b non-inferiority trial. Lancet Infect Dis. 2014 Jul;14(7):590-9.

[2]Xu L, Liu H, et al. Cobicistat (GS-9350): A Potent and Selective Inhibitor of Human CYP3A as a Novel Pharmacoenhancer. ACS Med Chem Lett. 2010 May 17;1(5):209-13.