Difloxacin HCl

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Chemical Structure| 91296-86-5 同义名 : Difloxacin (hydrochloride); A-56619
CAS号 : 91296-86-5
货号 : A418662
分子式 : C21H20ClF2N3O3
纯度 : 98+%
分子量 : 435.85
MDL号 : MFCD03840489
存储条件:

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Difloxacin (Hydrochloride) was the least active quinolone, particularly against Proteus, Morganella and Providencia spp. On a weight-for-weight basis, Difluoxacin Hydrochloride was the most active agents against Enterobacteriaceae (MIC90 = 0.12 mg/l)[1]. The minimum inhibitory concentration (MIC) and the minimum bactericidal concentration (MBC) of difloxacin against the field strain of E. coli O78 in vitro were 0.02 µg and 0.04 µg/ml, respectively. The systemic bioavailability of difloxacin following oral administration was 86.2% in healthy chickens and 90.6% in E. coli-infected birds[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.47mL

2.29mL

1.15mL

22.94mL

4.59mL

2.29mL

参考文献

[1]Digranes A, Dibb WL. In vitro activities of A-56619 (difloxacin) and A-56620, two aryl fluoroquinolones. Chemotherapy. 1988;34(4):298-307.

[2]Abo El-Ela FI, Radi AM, El-Banna HA, El-Gendy AA, Tohamy MA. Pharmacokinetics of difloxacin in healthy and E. coli-infected broiler chickens. Br Poult Sci. 2014;55(6):830-6.