SQ22536

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Chemical Structure| 17318-31-9 同义名 : NSC 53339; 9-(tetrahydrofuran-2-yl)-9h-purin-6-amine; SQ 22,536. NSC 53339
CAS号 : 17318-31-9
货号 : A417613
分子式 : C9H11N5O
纯度 : 99%+
分子量 : 205.22
MDL号 : MFCD00210216
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • AC
描述 SQ22536 is an effective inhibitor of forskolin's effects, with IC50 values reported at 5 μM. When preincubated with various concentrations, SQ22536 also effectively suppresses PACAP-induced reporter gene activation, with an approximate IC50 value of 5 μM. It more strongly inhibits Elk activation induced by forskolin (IC50=10 μM) compared to that induced by 8-Br-cAMP (IC50=170 μM). Notably, SQ22536 exhibits significant differences in potency when inhibiting the activities of recombinant AC5 and AC6, with IC50 values of 2 μM and 360 μM, respectively. At a higher concentration of 500 μM, SQ22536 markedly inhibits neurite elongation caused by either forskolin or 8-Br-cAMP[1].
作用机制 SQ 22536 is a 9-substituted adenine derivative.[1]
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.87mL

0.97mL

0.49mL

24.36mL

4.87mL

2.44mL

48.73mL

9.75mL

4.87mL
参考文献

[1]Harris DN, Asaad MM, et al. Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J Cyclic Nucleotide Res. 1979;5(2):125-34.

[2]Hourani SM, Boon K, et al. Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. Br J Pharmacol. 2001 Jul;133(6):833-40.

[3]Chen MC, Lin H, et al. Involvement of cAMP in nerve growth factor-triggered p35/Cdk5 activation and differentiation in PC12 cells. Am J Physiol Cell Physiol. 2010 Aug;299(2):C516-27.