Alizarin
产品说明书
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同义名 : | CI-58000; Anthraquinonic; NSC 7212 |
| CAS号 : | 72-48-0 | |
| 货号 : | A415687 | |
| 分子式 : | C14H8O4 | |
| 纯度 : | 95% | |
| 分子量 : | 240.21 | |
| MDL号 : | MFCD00001201 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | Among human P450s, CYP1A1, CYP1A2, CYP1B1 and CYP3A4 are involved in bioactivation of carcinogens such as heterocyclic amines and polycyclic aromatic compounds. CYP1A2 is expressed constitutively in hepatic tissues where most carcinogens are metabolized. CYP1A1 is induced on treatment with Ah-receptor binding agents. CYP1B1 is widely distributed in human extrahepatic tissues, and it is constitutively expressed and is inducible by Ah-receptor ligands[4]. Alizarin strongly inhibits the activities of CYP1A1, CYP1A2 and CYP1B1, with IC50 values of 6.2 μM, 10.0 μM and 2.7 μM, respectively, and weakly suppresses those of CYP2A6 and CYP2E1 in a dose-dependent manner, but do not inhibit those of CYP2C19, CYP3A4 and CYP3A5. CYP1B1 is the most strongly affected cytochrome P450 (CYP) molecule in a competitive manner by alizarin among CYPs examined in the study. The Km value of CYP1B1 is 11 μM, and the Ki value of alizarin against CYP1B1 is 0.5 μM[4]. Alizarin suppressed the mutagenicity of MeIQx in TA1538 1A2/OR or 1B1/OR, which suggested that the antigenotoxic activities of alizarin can be explained by inhibition of CYP activities responsible for activating the mutagens[4]. Alizarin was a very good antioxidant in their activity against iodophenol-derived phenoxyl radicals, superoxide anion radicals and lipid peroxidation in rat liver microsomes. In vivo experiment showed that alizarin reduced the hepatic content of thiobarbituric acid-reactive substances and lowered the serum level of alanine aminotransferase in poisoned animals [3]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.16mL 0.83mL 0.42mL |
20.82mL 4.16mL 2.08mL |
41.63mL 8.33mL 4.16mL |
| 参考文献 |
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[2]Antioxidant Activities of Baicalin, Green Tea Polyphenols and Alizarin in vitro and in vivo [3]Antioxidant Activities of Baicalin, Green Tea Polyphenols and Alizarin in vitro and in vivo |