Vactosertib HCl

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Chemical Structure| 1352610-25-3 同义名 : TEW-7197 Hydrochloride; EW-7197 Hydrochloride; Vactosertib Hydrochloride
CAS号 : 1352610-25-3
货号 : A410095
分子式 : C22H19ClFN7
纯度 : 98%
分子量 : 435.88
MDL号 : MFCD31619301
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Vactosertib Hydrochloride (also known as EW-7197 Hydrochloride) emerges as a potent, orally administered, and ATP-competitive inhibitor of activin receptor-like kinase 5 (ALK5), with an IC50 of 12.9 nM. It also effectively inhibits ALK2 and ALK4 at similar nanomolar concentrations, showing significant anti-metastatic and anti-cancer properties[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.29mL

0.46mL

0.23mL

11.47mL

2.29mL

1.15mL

22.94mL

4.59mL

2.29mL
参考文献

[1]Son JY, et al. EW-7197, a novel ALK-5 kinase inhibitor, potently inhibits breast to lung metastasis. Mol Cancer Ther. 2014 Jul;13(7):1704-16.

[2]Naka K, et al. Novel oral transforming growth factor-β signaling inhibitor EW-7197 eradicates CML-initiating cells. Cancer Sci. 2016 Feb;107(2):140-8.