GPR120 Agonist 3
产品说明书
 |
同义名 : | GPR120 Compound A; GPR120 cpdA; MDK77754 |
| CAS号 : | 1599477-75-4 | |
| 货号 : | A407926 | |
| 分子式 : | C19H23ClF3NO3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 405.84 | |
| MDL号 : | MFCD28975351 | |
| 存储条件： |
Pure form Sealed in dry, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | GPR120 Agonist 3 exhibits complete selectivity for Gpr120 (logEC50=-7.62) with negligible activity towards Gpr40. It induces a concentration-dependent increase in IP3 production in human and mouse Gpr120-expressing cells. GPR120 Agonist 3 elicits a concentration-dependent response in these cells, recruiting β-arrestin-2 with an EC50 of approximately 0.35 μM. It also potently and equivalently inhibits LPS-induced phosphorylation of Tak1, Ikkβ, and Jnk, and prevents the degradation of IκB[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.46mL 0.49mL 0.25mL |
12.32mL 2.46mL 1.23mL |
24.64mL 4.93mL 2.46mL |
