Vatalanib succinate
产品说明书
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同义名 : | PTK787 succinate; ZK-222584 succinate; CGP-79787 succinate |
| CAS号 : | 212142-18-2 | |
| 货号 : | A404860 | |
| 分子式 : | C24H21ClN4O4 | |
| 纯度 : | 99%+ | |
| 分子量 : | 464.9 | |
| MDL号 : | MFCD08435979 | |
| 存储条件： |
Pure form Inert atmosphere, store in freezer, under -20°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Vatalanib succinate is a potent, orally active VEGFR inhibitor with IC50s of 37 nM, 77 nM, 270 nM, 660 nM, 730 nM, 1,400 nM, and 580 nM for KDR, Flt-1, Flk, Flt-4, c-Kit, c-Fms, and PDGFR-β, respectively. Vatalanib succinate inhibits vascular endothelial growth factor-induced autophosphorylation of KDR and inhibits endothelial cell proliferation, migration and survival. At concentrations up to 1 µM, Vatalanib succinate does not have any cytotoxic or antiproliferative effects on cells that do not express VEGFR[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.15mL 0.43mL 0.22mL |
10.76mL 2.15mL 1.08mL |
21.51mL 4.30mL 2.15mL |
