生物活性 | |||
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描述 | Losartan Carboxylic Acid (E-3174), the active metabolite of Losartan featuring carboxylic acid, acts as an antagonist to the angiotensin II receptor type 1 (AT1). It displays Ki values of 0.97, 0.57, and 0.67 nM for rat AT1B/AT1A and human AT1, respectively. This compound inhibits angiotensin II-induced effects in vascular smooth muscle cells (VSMC) and increases plasma renin activity while lowering mean arterial pressure[1][2][3][4]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.29mL 0.46mL 0.23mL |
11.44mL 2.29mL 1.14mL |
22.89mL 4.58mL 2.29mL |
参考文献 |
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