MNS

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Chemical Structure| 1485-00-3 同义名 : 5-(2-Nitrovinyl)benzodioxole; NSC 170724; Syk Inhibitor III; NSC 105303; NSC 10120; MDBN; 3,4-Methylenedioxy-β-nitrostyrene
CAS号 : 1485-00-3
货号 : A400449
分子式 : C9H7NO4
纯度 : 98%
分子量 : 193.16
MDL号 : MFCD00014575
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • Syk

    Syk, IC50:2.5 μM

  • Syk

    Syk, IC50:2.5 μM

  • Src

    Src, IC50:29.3 μM

  • Src

    Src, IC50:29.3 μM

  • p97

    p97, IC50:1.7 μM
描述 MNS (NSC 170724), a beta-nitrostyrene derivative, functions as a potent tyrosine kinase inhibitor and a broad-spectrum antiplatelet agent. It completely inhibits platelet aggregation induced by U46619, ADP, arachidonic acid, collagen, and thrombin, with respective IC50 values of 2.1, 4.1, 5.8, 7.0, and 12.7 μM. MNS also inhibits Src, Syk, and focal adhesion kinase (FAK) with IC50 values of 27.3, 2.8, and 97.6 μM, highlighting its potential as a therapeutic agent in conditions where platelet aggregation and tyrosine kinase activities are implicated[1].[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.18mL

1.04mL

0.52mL

25.89mL

5.18mL

2.59mL

51.77mL

10.35mL

5.18mL
参考文献

[1]Wang WY, et al. Synthesis and pharmacological evaluation of novel beta-nitrostyrene derivatives as tyrosine kinase inhibitors with potent antiplatelet activity. Biochem Pharmacol. 2007;74(4):601-611.

[2]Wang WY, et al. Prevention of platelet glycoprotein IIb/IIIa activation by 3,4-methylenedioxy-beta-nitrostyrene, a novel tyrosine kinase inhibitor. Mol Pharmacol. 2006;70(4):1380-1389.