SKLB4771

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Chemical Structure| 1370256-78-2 同义名 : FLT3-IN-1
CAS号 : 1370256-78-2
货号 : A396655
分子式 : C25H27N7O3S2
纯度 : 99%+
分子量 : 537.66
MDL号 : MFCD28900746
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 SKLB4771 is a highly potent and selective inhibitor of Flt3, exhibiting an IC50 value of 10 nM. It suppresses the phosphorylation of FLT3/STAT5/ERK, hinders cell proliferation, and triggers apoptosis in tumor tissue [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.30mL

1.86mL

0.93mL

18.60mL

3.72mL

1.86mL
参考文献

[1]Li WW, et al. Discovery of the novel potent and selective FLT3 inhibitor 1-{5-[7-(3- morpholinopropoxy)quinazolin-4-ylthio]-[1,3,4]thiadiazol-2-yl}-3-p-tolylurea and its anti-acute myeloid leukemia (AML) activities in vitro and in vivo. J Med Chem. 2012 Apr 26;55(8):3852-66.

[2]Yan HX, et al. Accumulation of FLT3(+) CD11c (+) dendritic cells in psoriatic lesions and the anti-psoriatic effect of a selective FLT3 inhibitor. Immunol Res. 2014 Oct;60(1):112-26.