PD-166793
产品说明书
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同义名 : | - |
| CAS号 : | 199850-67-4 | |
| 货号 : | A395571 | |
| 分子式 : | C17H18BrNO4S | |
| 纯度 : | 95% | |
| 分子量 : | 412.3 | |
| MDL号 : | MFCD09038565 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | PD-166793 is a potent, selective, orally active, pan-MMP inhibitor with IC50 values of 4, 7, and 8 nM for MMP-2, MMP-3, and MMP-13, respectively, and 6.0, 7.2, and 7.9 μM for MMP-1, -7, and -9, respectively. PD-166793 reduces left ventricular remodeling and dysfunction in rat models of progressive heart failure[1][2][3].PD-166793 inhibited AMPD activity in rat heart homogenates by 20% at a concentration of 0.1 μM, and significantly reduced MMP-9 activity in normal human cardiac fibroblasts at a concentration of 100 μM for 36 h[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.43mL 0.49mL 0.24mL |
12.13mL 2.43mL 1.21mL |
24.25mL 4.85mL 2.43mL |
