R-IMPP
产品说明书
 |
同义名 : | PF-00932239 |
| CAS号 : | 2133832-83-2 | |
| 货号 : | A395105 | |
| 分子式 : | C24H27N3O2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 389.49 | |
| MDL号 : | MFCD31544323 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | R-IMPP is a PCSK9 secretion inhibitor with an IC50 value of 4.8 μM, targeting the 80S ribosome to inhibit PCSK9 protein translation. R-IMPP stimulates the uptake of LDL-C in hepatocellular carcinoma cells by increasing LDL-R levels, without altering the levels of secreted transferrin. R-IMPP does not reduce PCSK9 transcription or increase PCSK9 degradation but leads to transcription-dependent inhibition of PCSK9 translation. R-IMPP can selectively bind to human ribosomes but not to E. coli ribosomes[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.57mL 0.51mL 0.26mL |
12.84mL 2.57mL 1.28mL |
25.67mL 5.13mL 2.57mL |
