Gepotidacin

产品说明书

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Chemical Structure| 1075236-89-3 同义名 : GSK2140944
CAS号 : 1075236-89-3
货号 : A392519
分子式 : C24H28N6O3
纯度 : 99%
分子量 : 448.52
MDL号 : MFCD27987926
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Gepotidacin is a first in class triazaacenaphthylene antibiotic that inhibits bacterial type II DNA replication by inhibiting the activity of bacterial topoisomerase and has in vitro activity against susceptible and drug-resistant pathogens.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.15mL

2.23mL

1.11mL

22.30mL

4.46mL

2.23mL
参考文献

[1]Flamm RK, Farrell DJ, et al. Gepotidacin (GSK2140944) In Vitro Activity against Gram-positive and Gram-negative Bacteria (MBC/MIC, Kill Kinetics, Checkerboard, PAE/SME tests). Antimicrob Agents Chemother. 2017 May 8. pii: AAC.00468-17.

[2]O'Riordan W, Tiffany C, et al. The Efficacy, Safety, and Tolerability of Gepotidacin (GSK2140944) in the Treatment of Patients with Suspected or Confirmed Gram-Positive Acute Bacterial Skin and Skin Structure Infections. Antimicrob Agents Chemother. 2017 Apr 3. pii: AAC.02095-16.