Elesclomol

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Chemical Structure| 488832-69-5 同义名 : 伊利司莫(STA-4783) ;STA-4783
CAS号 : 488832-69-5
货号 : A384622
分子式 : C19H20N4O2S2
纯度 : 99%+
分子量 : 400.52
MDL号 : MFCD12911784
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

5% DMSO+40%PEG300+5%Tween80 +50%water 10 mg/mL

生物活性
描述 Elesclomol, an inhibitor of HSP90, is a potent oxidative stress inducer that elicits pro-apoptosis events among tumor cells.
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
647-V cell Growth inhibition assay Inhibition of human 647-V cell growth in a cell viability assay, IC50=6.9 nM SANGER
697 cell Growth inhibition assay Inhibition of human 697 cell growth in a cell viability assay, IC50=6.13 nM SANGER
A2780 cell Growth inhibition assay Inhibition of human A2780 cell growth in a cell viability assay, IC50=0.594 nM SANGER
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00088088 Stage IIIB Non-Small Cell Lung... 展开 >> Cancer Stage IV Non-Small Cell Lung Cancer 收起 << Phase 1 Phase 2 Completed - United States, Arkansas ... 展开 >> NEA Clinic Jonesboro, Arkansas, United States, 72401 United States, California Wilshire Oncology Medical Group Pamona, California, United States, 91767 St. Francis Memorial Hospital San Francisco, California, United States Cancer Institute Medical Group Santa Monica, California, United States, 90404 Kaiser Permanete Vallejo, California, United States United States, Connecticut Oncology Associates of Bridgeport Trumball, Connecticut, United States, 06611 United States, Florida ACORN Miami, Florida, United States Oncology Hematology Consultants Sarasota, Florida, United States, 34236 United States, Illinois University of Chicago Chicago, Illinois, United States, 60637 The Cancer Institute at Alexian Brothers Elk Grove Village, Illinois, United States, 60007 Ingalls Hospital Harvey, Illinois, United States, 60426 United States, Louisiana Overton Brooks, VAMC Shreveport, Louisiana, United States, 71101 LSUHSC - Shreveport Feist Weiller Cancer Center Shreveport, Louisiana, United States, 71130 United States, Maryland Maryland Hematology and Oncology Associates Baltimore, Maryland, United States, 21236 United States, Minnesota The Duluth Clinic Duluth, Minnesota, United States, 55805 United States, Tennessee The West Clinic Memphis, Tennessee, United States, 38120 The Sarah Cannon Research Center Nashville, Tennessee, United States, 37203 United States, Texas Presbyterian Hospital Dallas, Texas, United States, 75231 United States, Washington Multicare Health System Tacoma, Washington, United States, 98405 收起 <<
NCT00087997 Soft Tissue Sarcoma Phase 2 Completed - -
NCT00522834 Melanoma Phase 3 Terminated - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.48mL

2.50mL

1.25mL

24.97mL

4.99mL

2.50mL
参考文献

[1]Foy JP, Bazire L, et al. A 13-gene expression-based radioresistance score highlights the heterogeneity in the response to radiation therapy across HPV-negative HNSCC molecular subtypes. BMC Med. 2017;15(1):165.

[2]Kirshner JR, He S, et al. Elesclomol induces cancer cell apoptosis through oxidative stress. Mol Cancer Ther. 2008 Aug;7(8):2319-27.