Dichlorophen
产品说明书
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同义名 : | 双氯酚 ;DDM; Bis(5-chloro-2-hydroxyphenyl)methane; NSC 38642; Dichlorophene |
| CAS号 : | 97-23-4 | |
| 货号 : | A377668 | |
| 分子式 : | C13H10Cl2O2 | |
| 纯度 : | 98% | |
| 分子量 : | 269.12 | |
| MDL号 : | MFCD00002322 | |
| 存储条件： |
Pure form Keep in dark place, inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Dichlorophen is a chlorophenol fungicide. Dichlorophen ingestion results in life-threatening multiorgan dysfunction including rapid onset of caustic digestive lesions, diarrhea, liver enzyme disturbances, as well as acute kidney injury and rhabdomyolysis. Recovery can be complete if prompt supportive management is provided[2]. The in vitro and in vivo efficacy of dichlorophen (DCP), an antiparasitic agent for intestinal parasites, and silica nanoparticles modified with DCP (NP-DCP) was evaluated against E. multilocularis larval stage. Both formulations showed a time and dose-dependent in vitro effect against protoscoleces. In vivo studies demonstrated that the NP-DCP (4 mg kg-1) had similar efficacy to ABZ (25 mg kg-1) and greater activity than the free DCP[3]. Dichlorophen is advocated for tape worm, but was found to reduce the ova count by 83.3% and repeat treatment completely eradicated infection with F. buski[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.72mL 0.74mL 0.37mL |
18.58mL 3.72mL 1.86mL |
37.16mL 7.43mL 3.72mL |
| 参考文献 |
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