ZSET1446

产品说明书

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Chemical Structure| 887603-94-3 同义名 : ST-101
CAS号 : 887603-94-3
货号 : A368535
分子式 : C15H12N2O
纯度 : 97%
分子量 : 236.27
MDL号 : MFCD09970869
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 ZSET1446 is a cognitive enhancer that significantly improves learning deficits in various types of Alzheimer disease (AD) models.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.23mL

0.85mL

0.42mL

21.16mL

4.23mL

2.12mL

42.32mL

8.46mL

4.23mL
参考文献

[1]Takeda K, Yamaguchi Y, et al. Potentiation of Acetylcholine-Mediated Facilitation of Inhibitory Synaptic Transmission by an Azaindolizione Derivative, ZSET1446 (ST101), in the Rat Hippocampus. J Pharmacol Exp Ther. 2016 Feb;356(2):445-55.

[2]Yamaguchi Y, Takeda K, et al. Combination effects of ZSET1446/ST101 with memantine on cognitive function and extracellular acetylcholine in the hippocampus. J Pharmacol Sci. 2013;123(4):347-55.