Rimcazole 2HCl
产品说明书
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同义名 : | BW 234U dihydrochloride; Rimcazole dihydrochloride; Rimcazole dihydrochloride, Rimcazole 2HCl; BW 234U |
| CAS号 : | 75859-03-9 | |
| 货号 : | A363715 | |
| 分子式 : | C21H29Cl2N3 | |
| 纯度 : | 95% | |
| 分子量 : | 394.38 | |
| MDL号 : | MFCD00083199 | |
| 存储条件： |
Pure form Inert atmosphere, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Rimcazole 2HCl is a carbazole derivative that acts in part as a σ-receptor antagonist. Rimcazole 2HCl also binds with moderate affinity to the dopamine transporter and inhibits dopamine uptake. Rimcazole 2HCl reduces locomotor activity and sensitivity. Rimcazole 2HCl has also been used in cancer research[ 1][2][3][4].At a concentration range of 1-50 μM, acting for 24-48 hours, Rimcazole 2HCl reduces the number of HCT-116 cells (p53+/+ ) in a concentration-dependent manner[2].At a concentration of 50 μM, acting for 1-24 h, Rimcazole 2HCl induces transient accumulation of the HIF-1α protein in cancer cells (HCT-116 p53+/+ and MDA MB 231 cells), with a maximum at 6 h, whereas it does not in normal human dermal fibroblasts[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.54mL 0.51mL 0.25mL |
12.68mL 2.54mL 1.27mL |
25.36mL 5.07mL 2.54mL |
