Mitobronitol

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Chemical Structure| 488-41-5 同义名 : Myelobromol; DBM; 16dibromo16dideoxyDMannitol
CAS号 : 488-41-5
货号 : A360948
分子式 : C6H12Br2O4
纯度 : 97%
分子量 : 307.97
MDL号 : N/A
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Mitobronitol (Myelobromol; DBM) is a brominated derivative of mannitol, categorized as an alkylating agent with anticancer properties. It shows promise in myelosuppression, significantly reducing the risk of various complications associated with allogeneic bone marrow transplantation in accelerated chronic granulocytic leukemia [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.25mL

0.65mL

0.32mL

16.24mL

3.25mL

1.62mL

32.47mL

6.49mL

3.25mL
参考文献

[1]Silver RT, et al. A comparative study of dibromomannitol and busulfan in the treatment of chronic myeloid leukemia. A study of cancer and leukemia group B. Cancer. 1987 Oct 1;60(7):1442-8.

[2]Szebeni J, et al. Comparison of the lymphoid toxicities of mitobronitol and busulphan in mice: reduced B cell toxicity and improved thymic recovery as possible contributors to the reduced risk for complications following BMT with mitobronitol preconditioning. Leukemia. 1997 Oct;11(10):1769-74.