Azemiglitazone
产品说明书
 |
同义名 : | MSDC-0602 |
| CAS号 : | 1133819-87-0 | |
| 货号 : | A360389 | |
| 分子式 : | C19H17NO5S | |
| 纯度 : | 98+% | |
| 分子量 : | 371.41 | |
| MDL号 : | MFCD28502493 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Azemiglitazone, also known as MSDC-0602, is an orally active thiazolidinedione (TZD)-like molecule with low binding and activation affinity for PPARγ. Azemiglitazone inhibits the mitochondrial pyruvate carrier (MPC), thereby inhibiting Alzheimer's disease and attenuating non-alcoholic steatohepatitis (NASH)-induced liver injury[4][5].At a concentration of 15 μM for 4 hours, Azemiglitazone cross-links specifically with MPC and inhibits pyruvate oxidation and glucose production in hepatic mitochondria by interacting with MPC2[3].Azemiglitazone has a low binding and activation affinity for PPARγ, with an IC50 of 18.25 μM[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.69mL 0.54mL 0.27mL |
13.46mL 2.69mL 1.35mL |
26.92mL 5.38mL 2.69mL |
