Daclatasvir

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	同义名 :	达卡他韦 ;BMS-790052; EBP 883
	CAS号 :	1009119-64-5
	货号 :	A358801
	分子式 :	C₄₀H₅₀N₈O₆
	纯度 :	98%
	分子量 :	738.88
	MDL号 :	MFCD17129086
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
靶点	HCV Protease HCV NS5A, EC50:9 pM-50 pM HCV Protease HCV NS5A, EC50:9 pM-50 pM
描述	Daclatasvir is a first-in-class, highly-selective oral HCV NS5A inhibitor.

细胞研究
细胞系	浓度	检测类型	检测时间	活性说明	数据源
african green monkey Vero cells		Cytotoxicity assay		Cytotoxicity against african green monkey Vero cells, CC50=9.6 μM	23466233
human CEM cells		Cytotoxicity assay	3 days	Cytotoxicity against human CEM cells after 3 days, CC50=9.6 μM	25154714
human CEM cells		Cytotoxicity assay		Cytotoxicity against human CEM cells, CC50=9.6 μM	22704887

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT02095860	Hepatitis C	Phase 1	Completed	-	United States, Texas ... 展开 >> Healthcare Discoveries, Llc D/B/A Icon Development Solutions San Antonio, Texas, United States, 78209 收起 <<
NCT02531269	-		Completed	-	Switzerland ... 展开 >> Local Institution Basel, Switzerland 收起 <<
NCT03186313	Hepatitis C	Phase 3	Completed	-	Egypt ... 展开 >> Egyptian Liver Hospital Shirbīn, Dakahlia, Egypt, 35681 收起 <<

实验方案

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.35mL

0.27mL

0.14mL

6.77mL

1.35mL

0.68mL

13.53mL

2.71mL

1.35mL

参考文献

[1]Lee C, Ma H, et al. The hepatitis C virus NS5A inhibitor (BMS-790052) alters the subcellular localization of the NS5A non-structural viral protein. Virology. 2011 May 25;414(1):10-8.

[2]Gao M, Nettles RE, et al. Chemical genetics strategy identifies an HCV NS5A inhibitor with a potent clinical effect. Nature. 2010 May 6;465(7294):96-100.

✕

靶点

靶点	数值

HCV Protease	HCV NS5A, EC50:9 pM-50 pM
HCV Protease	HCV NS5A, EC50:9 pM-50 pM