同义名 :	-
	CAS号 :	60607-34-3
	货号 :	A357468
	分子式 :	C27H30N4O
	纯度 :	99%+
	分子量 :	426.55
	MDL号 :	MFCD00211147
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性
描述	Oxatomide, a strong and orally effective antagonist of both H1-histamine and P2X7 receptors, exhibits antihistamine and anti-allergic properties. It nearly fully inhibits ATP-induced currents in human P2X7 receptors with an IC50 of 0.95 μM, blocks ATP-induced Ca2+ influx with an IC50 of 0.43 μM, and also suppresses serotonin[1][2].

临床研究
NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00033813	Muscular Dystrophy, Duchenne	Phase 2	Completed	-	United States, District of Col... 展开 >>umbia Children's National Medical Center Washington, District of Columbia, United States, 20010 收起 <<

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.34mL 0.47mL 0.23mL	11.72mL 2.34mL 1.17mL	23.44mL 4.69mL 2.34mL

参考文献
[1]Kazuki Yoshida, et al. P2X7 receptor antagonist activity of the anti-allergic agent oxatomide. Eur J Pharmacol. 2015 Nov 15;767:41-51. [2]K Ohmori, et al. Pharmacological studies on oxatomide (KW-4354). (7) Antagonistic effects on chemical mediators. Nihon Yakurigaku Zasshi. 1983 May;81(5):399-409.