Ellipticine HCl

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Chemical Structure| 5081-48-1 同义名 : NSC 71795 hydrochloride; Ellipticine hydrochloride; PZE
CAS号 : 5081-48-1
货号 : A354526
分子式 : C17H15ClN2
纯度 : 99%+
分子量 : 282.77
MDL号 : MFCD00050600
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Ellipticine (NSC 71795) is a powerful antineoplastic agent, leveraging multiple mechanisms for its antitumor, mutagenic, and cytotoxic effects. Its actions include DNA intercalation and inhibition of DNA topoisomerase II activity, as well as the creation of covalent DNA adducts through oxidation processes facilitated by cytochromes P450 (CYP) and peroxidases[1]. Ellipticine's capability to act both as an inhibitor and inducer of biotransformation enzymes further influences its metabolism, contributing to its genotoxic and pharmacological outcomes. Cellular exposure to Ellipticine results in inhibited growth and proliferation, linked to the formation of two specific covalent Ellipticine-derived DNA adducts[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.54mL

0.71mL

0.35mL

17.68mL

3.54mL

1.77mL

35.36mL

7.07mL

3.54mL
参考文献

[1]Stiborova M, et al. Molecular mechanisms of antineoplastic action of an anticancer drug ellipticine. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2006 Jul;150(1):13-23.

[2]Stiborova M, et al. Ellipticine cytotoxicity to cancer cell lines - a comparative study. Interdiscip Toxicol. 2011 Jun;4(2):98-105.

[3]Stiborova M, et al. The anticancer drug ellipticine activated with cytochrome P450 mediates DNA damage determining its pharmacological efficiencies: studies with rats, Hepatic Cytochrome P450 Reductase Null (HRN?) mice and pure enzymes. Int J Mol Sci. 2014 Dec 25;16(1):284-306.