GW842166X

产品说明书

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Chemical Structure| 666260-75-9 同义名 : -
CAS号 : 666260-75-9
货号 : A349765
分子式 : C18H17Cl2F3N4O2
纯度 : 99%
分子量 : 449.25
MDL号 : MFCD11045840
存储条件：

Pure form Keep in dark place, inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 GW842166X is a potent and highly selective agonist of cannabinoid receptor CB2 receptor with EC50 of 63 nM, shows no significant activity at CB1 receptor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.23mL

0.45mL

0.22mL

11.13mL

2.23mL

1.11mL

22.26mL

4.45mL

2.23mL
参考文献

[1]Yao BB, Hsieh GC, et al. In vitro and in vivo characterization of A-796260: a selective cannabinoid CB2 receptor agonist exhibiting analgesic activity in rodent pain models. Br J Pharmacol. 2008 Jan;153(2):390-401.

[2]Giblin GM, O'Shaughnessy CT, et al. Discovery of 2-[(2,4-dichlorophenyl)amino] -N-[(tetrahydro-2H-pyran-4-yl)methyl] -4-(trifluoromethyl)- 5-pyrimidinecarboxamide, a selective CB2 receptor agonist for the treatment of inflammatory pain. J Med Chem. 2007 May 31;50(11):2597-600.