Licochalcone A

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Chemical Structure| 58749-22-7 同义名 : -
CAS号 : 58749-22-7
货号 : A341742
分子式 : C21H22O4
纯度 : 99%+
分子量 : 338.4
MDL号 : MFCD01417903
存储条件：

Pure form Keep in dark place, sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Licochalcone A (LA) is a flavonoid extracted from licorice root and has antiparasitic and anti-tumor activities[3]. Treatment with LA at 6.25 or 12.5 μM for 24 h down-regulated the expression of Bcl-2 with concomitant enhancement of the conversion of LC3-I to LC3-II and dose-dependently induced apoptosis in LNCaP cells[4]. BGC cells exposed to LA (100 μM) for 2 or 4 h showed significantly increased intracellular ROS in a concentration-dependent manner, activated ERK, JNK, and p38 but suppressed PI3K and AKT, compared with the control group[3]. Licochalcone A showed effects against all gram-positive bacteria tested and was especially effective against Bacillus cereus IFO 3514, Bacillus coagulans IFO 12583, Bacillus subtilis IFO 3007 and Bacillus stearothermophilus IFO 12550, with MICs of 2 to 3 μg/mL, but was not effective against gram-negative bacteria or eukaryotes at 50 μg/mL[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.96mL

0.59mL

0.30mL

14.78mL

2.96mL

1.48mL

29.55mL

5.91mL

2.96mL
参考文献

[1]Hao W, Yuan X, et al. Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015 May 18;5:10336.

[2]Tsukiyama R, Katsura H, et al. Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrob Agents Chemother. 2002 May;46(5):1226-30.

[3]Hao W, Yuan X, Yu L, Gao C, Sun X, Wang D, Zheng Q. Licochalcone A-induced human gastric cancer BGC-823 cells apoptosis by regulating ROS-mediated MAPKs and PI3K/AKT signaling pathways. Sci Rep. 2015 May 18;5:10336. doi: 10.1038/srep10336. PMID: 25981581; PMCID: PMC4434846.

[4]Yo YT, Shieh GS, Hsu KF, Wu CL, Shiau AL. Licorice and licochalcone-A induce autophagy in LNCaP prostate cancer cells by suppression of Bcl-2 expression and the mTOR pathway. J Agric Food Chem. 2009 Sep 23;57(18):8266-73. doi: 10.1021/jf901054c. PMID: 19711916.

[5]Tsukiyama R, Katsura H, Tokuriki N, Kobayashi M. Antibacterial activity of licochalcone A against spore-forming bacteria. Antimicrob Agents Chemother. 2002 May;46(5):1226-30. doi: 10.1128/AAC.46.5.1226-1230.2002. PMID: 11959549; PMCID: PMC127195.