同义名 :	地弗拉松
	CAS号 :	2557-49-5
	货号 :	A331088
	分子式 :	C22H28F2O5
	纯度 :	99+%
	分子量 :	410.45
	MDL号 :	MFCD00200358
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Diflorasone act as a corticosteroid hormone receptor agonist with anti-inflammatory and immunosuppressive properties. Diflorasone enters the cell by diffusion across the cell membrane and binds to the glucocorticoid receptor (GR) in the cytoplasm[1]. 0.05% diflorasone diacetate cream was as effective as 0.05% fluocinonide cream in the therapy of lesions of psoriasis or atopic/neurodermatitis[2]. Diflorasone inhibits RANTES and thymus and activation regulated chemokine (TARC) in a dinitrochlorobenzene-induced mouse model of allergic contact dermatitis[3]. It also inhibits proliferation of human keratinocytes in vitro and reduces epidermal thickening in a mouse model of psoriasis induced by imiquimod[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.44mL 0.49mL 0.24mL	12.18mL 2.44mL 1.22mL	24.36mL 4.87mL 2.44mL

参考文献

[1]Wickrema Sinha AJ, Shaw SR, Weber DJ. Percutaneous absorption and excretion of tritium-labeled diflorasone diacetate, a new topical corticosteroid in the rat, monkey and man. J Invest Dermatol. 1978 Dec;71(6):372-7 [2]Bluefarb SM, Howard FM, Leibsohn E, Schlagel CA, Wexler L. Diflorasone diacetate: vasoconstrictor activity and clinical efficacy of a new topical corticosteroid. J Int Med Res. 1976;4(6):454-61 [3]Bäumer, W., Seegers, U., Braun, M., et al. TARC and RANTES, but not CTACK, are induced in two models of allergic contact dermatitis. Effects of cilomilast and diflorasone diacetate on T-cell-attracting chemokines. Br. J. Dermatol. 2004; 151(4): 823-830 [4] Schaper, K., Dickhaut, J., Japtok, L., et al. Sphingosine-1-phosphate exhibits anti-proliferative and anti-inflammatory effects in mouse models of psoriasis. J. Dermatol. Sci. 2013; 71(1): 29-36 (2013).