PHD-1-IN-1

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Chemical Structure| 2009343-14-8 同义名 : -
CAS号 : 2009343-14-8
货号 : A330928
分子式 : C13H8N4
纯度 : 99%+
分子量 : 220.23
MDL号 : MFCD34470407
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PHD-1 inhibitor C17 is an early lead compound of 4-{[1,2,4]triazolo[1,5-a]pyridin-5-yl}benzonitrile-based inhibitors of the hypoxia-inducible factor (HIF) prolylhydroxylase domain-1 (PHD-1) showing a moderate rate of microsomal turnover in vitro.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.54mL

0.91mL

0.45mL

22.70mL

4.54mL

2.27mL

45.41mL

9.08mL

4.54mL
参考文献

[1]Ahmed S, Ayscough A, et al. 1,2,4-Triazolo-[1,5-a] pyridine HIF Prolylhydroxylase Domain-1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction. J Med Chem. 2017 Jun 24.