Albendazole

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Chemical Structure| 54965-21-8 同义名 : SKF-62979; ABZ; Valbazen; Albenza; Zentel; Eskazole; NSC 220008
CAS号 : 54965-21-8
货号 : A330367
分子式 : C12H15N3O2S
纯度 : 98%
分子量 : 265.33
MDL号 : MFCD00083232
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Albendazole is a derivative of benzimidazole that shows anthelmintic activity against nematode, cestode, and trematode species[3]. It inhibited HT-29 cell proliferation with an IC50 value of 0.12μM. Albendazole at a dosage of 1μM induced cell cycle arrest and apoptotic cell death in HT-29 cells at 24h post-treatment[4]. Albendazole also inhibited mammalian tubulin polymerization (IC50=6.9μM), [3H]mebendazole binding to H. contortus L3 larval tubulin (IC50=0.21μM), egg-hatch (ED50=0.38μM), and larval development activity (LD50=0.034μM)[5]. Albendazole at 150mg/kg (i.p.) suppressed tumor growth in nude mice inoculated with HT-29 cells when given as a single-dose treatment, once a week, or on alternate days for 6 weeks[4]. In mice infected with the embryonated ova of Ascaris suum, pretreatment with albendazole at 0.05% of the diet for 11 days protected mice against lethal effects of the migrating larvae[3].
作用机制 Albendazole is a derivative of benzimidazole that inhibits mammalian tubulin polymerization and tumor cell growth[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.84mL

3.77mL

1.88mL

37.69mL

7.54mL

3.77mL
参考文献

[1]Uckermann O, Kutzera F, et al. The glucocorticoid triamcinolone acetonide inhibits osmotic swelling of retinal glial cells via stimulation of endogenous adenosine signaling. J Pharmacol Exp Ther. 2005 Dec;315(3):1036-45.

[2]Whittaker SG, Faustman EM. Effects of albendazole and albendazole sulfoxide on cultures of differentiating rodent embryonic cells. Toxicol Appl Pharmacol. 1991 Jun 1;109(1):73-84.

[3]Theodorides VJ, Gyurik RJ, Kingsbury WD, Parish RC. Anthelmintic activity of albendazole against liver flukes, tapeworms., lung and gastrointestinal roundworms. Experientia. 1976;32(6):702-703.

[4]Pourgholami MH, Akhter J, Wang L, Lu Y, Morris DL. Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: in vitro and in a xenograft model of peritoneal carcinomatosis. Cancer Chemother Pharmacol. 2005;55(5):425-432.

[5]Lacey E. Mode of action of benzimidazoles. Parasitol Today. 1990;6(4):112-115.