GET73
产品说明书
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同义名 : | - |
| CAS号 : | 202402-01-5 | |
| 货号 : | A330195 | |
| 分子式 : | C13H16F3NO2 | |
| 纯度 : | 99%+ | |
| 分子量 : | 275.27 | |
| MDL号 : | MFCD31812537 | |
| 存储条件： |
Pure form Sealed in dry, room temperature In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | γ-Hydroxybutyrate (GHB) is a four-carbon chain monocarboxylic acid that is naturally present in the mammalian central nervous system (CNS). GET-73, a GHB analog, shows effect on hippocampal glutamate transmission. The microdialysis results indicated that local perfusion (60 min) with 10 μM – 1 μM GET73 increased extracellular glutamate levels in the CA1 region of the hippocampus of freely moving rats in a concentration dependent manner. In tissue slices from the rat hippocampus, treatment with 1 μM GET73 significantly increased K+-evoked, but not spontaneous, glutamate efflux. Moreover, 500 nM GET73 partially but significantly counteracted the increase in K+-evoked glutamate efflux induced by 100 μM CHPG, an mGluR5 agonist. These findings demonstrate that the GHB analog GET73 significantly affects glutamate transmission in the hippocampus[3]. Interestingly, the addiction of GET73 (1 and 10 µM) 1 h before and during chronic ethanol exposure prevented all the ethanol-induced effects (such as: a reduction of cell viability, an alteration of cytoskeleton, a decrease in extracellular glutamate levels and an increase of reactive oxygen species production)[4]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.63mL 0.73mL 0.36mL |
18.16mL 3.63mL 1.82mL |
36.33mL 7.27mL 3.63mL |
| 参考文献 |
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