同义名 :	-
	CAS号 :	581073-80-5
	货号 :	A326728
	分子式 :	C22H15N3O4
	纯度 :	99%+
	分子量 :	385.37
	MDL号 :	MFCD29081199
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

KJ Pyr 9 (KJ-Pyr-9) acts by disrupting the MYC-MAX complex formation within cells, as observed in protein fragment complementation assays[1]. KJ Pyr 9 specifically targets and inhibits MYC-induced oncogenic transformation in cell cultures, showing minimal or negligible impact on the oncogenic functions of various unrelated oncoproteins[1]. KJ Pyr 9 notably affects the proliferation of cells overexpressing MYC, both human and avian, and distinctively reduces the transcriptional signature driven by MYC[1]. KJ Pyr 9 efficacy has been tested against three cell lines known for their dependence on enhanced MYC activity: NCI-H460, MDA-MB-231, and SUM-159PT, successfully inhibiting their proliferation with IC50 values ranging between 5 and 10 μM[1]. Burkitt lymphoma cell lines, characterized by constitutively high c-MYC expression, show even greater sensitivity to KJ Pyr 9, with IC50 values between 1 and 2.5 μM[1].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	2.59mL 0.52mL 0.26mL	12.97mL 2.59mL 1.30mL	25.95mL 5.19mL 2.59mL

参考文献
[1]Hart JR, et al. Inhibitor of MYC identified in a Kröhnke pyridine library. Proc Natl Acad Sci U S A. 2014 Aug 26;111(34):12556-61.