生物活性 | |||
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描述 | Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal. A paste formulation of pyrantel pamoate, at a dosage of 13.2 mg/kg, was 97.3% effective against a ML-R (macrocyclic lactone, ML) isolate of P. equorum[3]. Pyrantel is an antihelminthic that acts as an agonist of nicotinic acetylcholine receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Consequently, there may be an association between pyrantel pamoate and MG(Myasthenia gravis) [4]. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53) [5]. A single, oral treatment of pyrantel pamoate paste (19.13% w/w pyrantel base) at 13.2mg/kg was >or=95.5% effective against A. perfoliata in naturally-infected horses[6]. Pyrantel pamoate paste (19.13%, w/w, pyrantel base) administered orally at a dosage of 13.2 mg pyrantel base/kg b.w. is highly efficacious (95%) against Anoplocephala spp. and safe for use in horses with no adverse clinical or neurological health events observed under field use conditions[7]. |
临床研究 | |||||
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NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
NCT02047669 | Musculoskeletal Disorders ... 展开 >> Stress 收起 << | Not Applicable | Completed | - | Denmark ... 展开 >> National Research Centre for the Working Environment Copenhagen, Denmark, 2100 收起 << |
NCT02939677 | Rupture of Anterior Cruciate L... 展开 >>igament Muscle Degeneration Gait, Unsteady 收起 << | Not Applicable | Recruiting | December 2019 | Denmark ... 展开 >> Orthopaedic Research Unit, Institute of Clinical Research, SDU Recruiting Odense, Region Of Southern Denmark, Denmark, 5000 Contact: Anders Holsgaard-Larsen, Ass.Prof. +45 6550 3903 AHLarsen@health.sdu.dk Contact: Soren Overgaard, Professor +45 6541 2286 soeren.overgaard@rsyd.dk 收起 << |
NCT01616667 | Unilateral Primary Osteoarthri... 展开 >>tis of Hip 收起 << | Phase 2 | Completed | - | Denmark ... 展开 >> Odense University Hospital Odense, Denmark, 5000 C 收起 << |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.68mL 0.34mL 0.17mL |
8.41mL 1.68mL 0.84mL |
16.82mL 3.36mL 1.68mL |
参考文献 |
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