Pyrantel pamoate

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Chemical Structure| 22204-24-6 同义名 : Pyrantel embonate; Pyrantel (pamoate); CP 10423-16
CAS号 : 22204-24-6
货号 : A322375
分子式 : C34H30N2O6S
纯度 : 97%
分子量 : 594.68
MDL号 : MFCD00072037
存储条件:

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Pyrantel pamoate is a deworming agent in the treatment of hookworms (all species) and roundworms in domesticated animal. A paste formulation of pyrantel pamoate, at a dosage of 13.2 mg/kg, was 97.3% effective against a ML-R (macrocyclic lactone, ML) isolate of P. equorum[3]. Pyrantel is an antihelminthic that acts as an agonist of nicotinic acetylcholine receptors (AChRs) of nematodes and exerts its therapeutic effects by depolarizing their muscle membranes. Consequently, there may be an association between pyrantel pamoate and MG(Myasthenia gravis) [4]. Combinations of oxantel pamoate with pyrantel pamoate behaved antagonistically in vitro (combination index (CI) = 2.53) [5]. A single, oral treatment of pyrantel pamoate paste (19.13% w/w pyrantel base) at 13.2mg/kg was >or=95.5% effective against A. perfoliata in naturally-infected horses[6]. Pyrantel pamoate paste (19.13%, w/w, pyrantel base) administered orally at a dosage of 13.2 mg pyrantel base/kg b.w. is highly efficacious (95%) against Anoplocephala spp. and safe for use in horses with no adverse clinical or neurological health events observed under field use conditions[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02047669 Musculoskeletal Disorders ... 展开 >> Stress 收起 << Not Applicable Completed - Denmark ... 展开 >> National Research Centre for the Working Environment Copenhagen, Denmark, 2100 收起 <<
NCT02939677 Rupture of Anterior Cruciate L... 展开 >>igament Muscle Degeneration Gait, Unsteady 收起 << Not Applicable Recruiting December 2019 Denmark ... 展开 >> Orthopaedic Research Unit, Institute of Clinical Research, SDU Recruiting Odense, Region Of Southern Denmark, Denmark, 5000 Contact: Anders Holsgaard-Larsen, Ass.Prof.    +45 6550 3903    AHLarsen@health.sdu.dk    Contact: Soren Overgaard, Professor    +45 6541 2286    soeren.overgaard@rsyd.dk 收起 <<
NCT01616667 Unilateral Primary Osteoarthri... 展开 >>tis of Hip 收起 << Phase 2 Completed - Denmark ... 展开 >> Odense University Hospital Odense, Denmark, 5000 C 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.68mL

0.34mL

0.17mL

8.41mL

1.68mL

0.84mL

16.82mL

3.36mL

1.68mL

参考文献

[1]Reinemeyer CR, Prado JC, et al. Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses. Vet Parasitol. 2010 Jul 15;171(1-2):111-5.

[2]Salman AB. Management of intestinal obstruction caused by ascariasis. J Pediatr Surg. 1997 Apr;32(4):585-7.

[3]Reinemeyer CR, Prado JC, Nichols EC, Marchiondo AA. Efficacy of pyrantel pamoate against a macrocyclic lactone-resistant isolate of Parascaris equorum in horses. Vet Parasitol. 2010;171(1-2):111‐115

[4]Shen C, Li M, Zhao X, Cui L. An ocular myasthenia gravis attack after oral pyrantel pamoate: An unusual case report. Medicine (Baltimore). 2019;98(27):e16321

[5]Keiser J, Tritten L, Silbereisen A, Speich B, Adelfio R, Vargas M. Activity of oxantel pamoate monotherapy and combination chemotherapy against Trichuris muris and hookworms: revival of an old drug. PLoS Negl Trop Dis. 2013;7(3):e2119

[6]Reinemeyer CR, Hutchens DE, Eckblad WP, Marchiondo AA, Shugart JI. Dose-confirmation studies of the cestocidal activity of pyrantel pamoate paste in horses. Vet Parasitol. 2006;138(3-4):234‐239

[7]Marchiondo AA, White GW, Smith LL, et al. Clinical field efficacy and safety of pyrantel pamoate paste (19.13% w/w pyrantel base) against Anoplocephala spp. in naturally infected horses. Vet Parasitol. 2006;137(1-2):94‐102