BU224 HCl
产品说明书
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同义名 : | BU224 hydrochloride |
| CAS号 : | 205437-64-5 | |
| 货号 : | A320075 | |
| 分子式 : | C12H12ClN3 | |
| 纯度 : | 97% | |
| 分子量 : | 233.7 | |
| MDL号 : | MFCD00467639 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | BU224 hydrochloride is distinguished as a selective ligand with high affinity for the imidazoline I2 receptor, evidenced by a Ki value of 2.1 nM. It is occasionally employed as an antagonist for the I2 receptor. The compound is noted for its neuroprotective qualities, including anti-inflammatory and anti-apoptotic effects. In the context of Alzheimer's disease research, BU224 hydrochloride has been shown to enhance memory in 5XFAD mice models, contributing to the enlargement of dendritic spines and mitigating the alterations in NMDARs induced by Aβ[1][2][3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.28mL 0.86mL 0.43mL |
21.39mL 4.28mL 2.14mL |
42.79mL 8.56mL 4.28mL |
