SRT 2183

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Chemical Structure| 1001908-89-9 同义名 : -
CAS号 : 1001908-89-9
货号 : A318652
分子式 : C27H24N4O2S
纯度 : 99%
分子量 : 468.57
MDL号 : MFCD22419825
存储条件:

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 SRT 2183 is a selective activator of Sirtuin-1 (SIRT1), with an EC1.5 of 0.36 μM[1]. SRT 2183 triggers growth arrest and apoptosis, along with the deacetylation of STAT3 and NF-κB, and a decrease in c-Myc protein levels[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.13mL

0.43mL

0.21mL

10.67mL

2.13mL

1.07mL

21.34mL

4.27mL

2.13mL

参考文献

[1]Milne JC, et al. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes. Nature. 2007 Nov 29; 450(7170): 712–716.

[2]Scuto A, et al. SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells. Cell Death Dis. 2013 May; 4(5): e635.

[3]Gurt I, et al. The Sirt1 Activators SRT2183 and SRT3025 Inhibit RANKL-Induced Osteoclastogenesis in Bone Marrow-Derived Macrophages and Down-Regulate Sirt3 in Sirt1 Null Cells. PLoS One. 2015 Jul 30;10(7):e0134391.