Nimbolide

产品说明书

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Chemical Structure| 25990-37-8 同义名 : NSC 309909
CAS号 : 25990-37-8
货号 : A315401
分子式 : C27H30O7
纯度 : 98+%
分子量 : 466.52
MDL号 : MFCD28137747
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Nimbolide is a terpenoid lactone isolated and purified from A. indica (Neem tree) that demonstrates antimalarial and anticancer effects in experimental models.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.14mL

0.43mL

0.21mL

10.72mL

2.14mL

1.07mL

21.44mL

4.29mL

2.14mL
参考文献

[1]Subramani R, Gonzalez E, et al. Nimbolide inhibits pancreatic cancer growth and metastasis through ROS-mediated apoptosis and inhibition of epithelial-to-mesenchymal transition. Sci Rep. 2016 Jan 25;6:19819.

[2]Gupta SC, Reuter S, et al. Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax. J Biol Chem. 2011 Jan 14;286(2):1134-46.