同义名 :	Amezinium metilsulfate; Lu-1631; Risumic; Regulton; methylsulfate; Amezinium
	CAS号 :	30578-37-1
	货号 :	A313059
	分子式 :	C12H15N3O5S
	纯度 :	98%
	分子量 :	313.33
	MDL号 :	MFCD00865972
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Amezinium metilsulfate is a sympathomimetic drug used for the treatment of low blood pressure. During spinal/epidural anaesthesia 5 mg amezinium is given i.v. if blood pressure dropped greater than 20 mmHg. Amezinium proves a stimulating drug for alpha- and beta 1-receptors by stabilising the systemic blood pressure in spinal/epidural anaesthesia[3]. Amezinium metilsulfate most probably stimulates both alpha1B-receptors in the vascular wall and alpha1A/D-receptors in the proximal urethra[4]. Moreover, amezinium is of therapeutic value for the treatment of neurogenic orthostatic hypotension[5].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.19mL 0.64mL 0.32mL	15.96mL 3.19mL 1.60mL	31.92mL 6.38mL 3.19mL

参考文献

[1]Kitano Y, Nomura S, et al. Leg ulceration during amezinium methylsulfate therapy for hypotension in a hemodialyzed patient with generalized vascular calcification. Nephron. 1995;71(1):115. [2]Nambu K, Yoshida K, et al. Disposition and metabolism of [14C] -amezinium metilsulfate in rats. Arzneimittelforschung. 1988 Jul;38(7):909-18. [3]Schaps D, Seitz W, Mehler D, Tholen A, Goroll D. Therapeutische Anwendung von Ameziniummetilsulfat--einem neuen, langwirkenden Sympathikomimetikum--bei rückenmarksnaher Leitungsanästhesie [Therapeutic use of amezinium methylsulfate--a new, long acting, sympathomimetic--in paraspinal conduction anesthesia]. Anasth Intensivther Notfallmed. 1984 Oct;19(5):235-9. German. PMID: 6517242. [4]Sakakibara R, Uchiyama T, Asahina M, Yoshiyama M, Yamanishi T, Hattori T. Amezinium metilsulfate, a sympathomimetic agent, may increase the risk of urinary retention in multiple system atrophy. Clin Auton Res. 2003 Feb;13(1):51-3. [5]Kita K, Hirayama K. Treatment of neurogenic orthostatic hypotension with amezinium metilsulfate, a new indirect sympathomimetic drug. Neurology. 1988 Jul;38(7):1095-9.