EN460

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Chemical Structure| 496807-64-8 同义名 : -
CAS号 : 496807-64-8
货号 : A312147
分子式 : C22H12ClF3N2O4
纯度 : 98%
分子量 : 460.79
MDL号 : MFCD02951227
存储条件：

Pure form Sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 EN460 is a small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) and interacts selectively (IC50=1.9 μM) with the reduced, active form of ERO1α and prevents its reoxidation.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.17mL

0.43mL

0.22mL

10.85mL

2.17mL

1.09mL

21.70mL

4.34mL

2.17mL
参考文献

[1]Blais JD, Chin KT, et al. A small molecule inhibitor of endoplasmic reticulum oxidation 1 (ERO1) with selectively reversible thiol reactivity. J Biol Chem. 2010 Jul 2;285(27):20993-1003.