Pardoprunox HCl

产品说明书

Print
Chemical Structure| 269718-83-4 同义名 : DU-126891 hydrochloride; SLV-308 hydrochloride; SLV 308; DU-126891; Pardoprunox (hydrochloride); SME-308 hydrochloride; Pardoprunox hydrochloride
CAS号 : 269718-83-4
货号 : A308996
分子式 : C12H16ClN3O2
纯度 : 99%+
分子量 : 269.73
MDL号 : MFCD09833663
存储条件：

Pure form Inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Pardoprunox (SLV-308) hydrochloride is a partial agonist at dopamine D2 and D3 receptors, with pEC50s of 8 and 9.2, respectively, and acts as a serotonin 5-HT1A receptor agonist with a pEC50 of 6.3[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.71mL

0.74mL

0.37mL

18.54mL

3.71mL

1.85mL

37.07mL

7.41mL

3.71mL
参考文献

[1]Glennon JC, et al. In vitro characterization of SLV308 (7-[4-methyl-1-piperazinyl]-2(3H)-benzoxazolone, monohydrochloride): a novel partial dopamine D2 and D3 receptor agonist and serotonin 5-HT1A receptor agonist. Synapse. 2006 Dec 15;60(8):599-608.

[2]Stephanie Pei Tung Yiu, et al. Intracellular Iron Chelation by a Novel Compound, C7, Reactivates Epstein–Barr Virus (EBV) Lytic Cycle via the ERK-Autophagy Axis in EBV-Positive Epithelial Cancers Cancers 2018 Dec; 10(12): 505.