CWHM-12

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Chemical Structure| 1564286-55-0 同义名 : -
CAS号 : 1564286-55-0
货号 : A297047
分子式 : C26H32BrN5O6
纯度 : 98%
分子量 : 590.47
MDL号 : MFCD28385850
存储条件：

Pure form Keep in dark place, sealed in dry, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 CWHM-12 exhibits selective inhibition towards a range of integrins, demonstrating significant potency against αvβ1, αvβ3, αvβ6, and αvβ8 in vitro ligand-binding assays. It shows a reduced potency against αvβ5 with an IC50 value of 61 nM, while showing much less effectiveness against αIIbβ3, α2β1, and α10β1, where the IC50 values exceed 5000 nM. This highlights CWHM-12's targeted inhibitory action mainly towards the αv integrin family[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.69mL

0.34mL

0.17mL

8.47mL

1.69mL

0.85mL

16.94mL

3.39mL

1.69mL
参考文献

[1]Henderson NC, et al. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec;19(12):1617-24.