同义名 :	哌立度酯
	CAS号 :	82-98-4
	货号 :	A294526
	分子式 :	C21H25NO2
	纯度 :	98%
	分子量 :	323.43
	MDL号 :	MFCD00242588
	存储条件：	Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Piperidolate is an antimuscarinic, inhibits intestinal cramp induced by acetylcholine (rats and dogs) [3]. The mouse writhing test has been used to evaluate analgesic drugs. Atropine sulfate and eight of its substitutes have the protective effect of acetic acid-induced writhing in mice. Dicyclomine hydrochloride and orphenadrine hydrochloride produced an effect comparable with that of noramidopyrine, while atropine sulphate, oxyphenonium bromide and piperidolate hydrochloride were less potent[4].

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.09mL 0.62mL 0.31mL	15.46mL 3.09mL 1.55mL	30.92mL 6.18mL 3.09mL

参考文献

[1]Hara M, Harberg FJ, Hudson LH. Antifibrillatory action of piperidolate hydrochloride (dactil) in hypothermia. AMA Arch Surg. 1957 Nov;75(5):780-4. [2]PIPERIDOLATE hydrochloride. J Am Med Assoc. 1957 May 18;164(3):281. [3]PIPERIDOLATE hydrochloride. J Am Med Assoc. 1957;164(3):281 [4]Kelkar MS. Atropine substitutes and the writhing syndrome in mice. Arch Int Pharmacodyn Ther. 1977;229(1):133‐137