Mericitabine

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Chemical Structure| 940908-79-2 同义名 : RG 7128; R-7128; 3',5'-Diisobutyryl PSI 6130; PSI 6130 diisobutyrate
CAS号 : 940908-79-2
货号 : A293785
分子式 : C18H26FN3O6
纯度 : 97%
分子量 : 399.41
MDL号 : MFCD22572932
存储条件：

Pure form Keep in dark place, inert atmosphere, 2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 R7128 is a selective nucleoside analog inhibitor of the hepatitis C virus (HCV) NS5B RNA-dependent RNA polymerase, with activity across all HCV genotypes.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.50mL

0.50mL

0.25mL

12.52mL

2.50mL

1.25mL

25.04mL

5.01mL

2.50mL
参考文献

[1]Le Pogam S, Yan JM, et al. Characterization of hepatitis C virus(HCV) quasispecies dynamics upon short-term dual therapy with the HCV NS5B nucleoside polymerase inhibitor mericitabine and the NS3/4 protease inhibitor danoprevir. Antimicrob Agents Chemother. 2012 Nov;56(11):5494-502.

[2]Soriano V, Vispo E, et al. Directly acting antivirals against hepatitis C virus. J Antimicrob Chemother. 2011 Aug;66(8):1673-86.