Propyl pyrazole triol
产品说明书
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同义名 : | PPT |
| CAS号 : | 263717-53-9 | |
| 货号 : | A293266 | |
| 分子式 : | C24H22N2O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 386.44 | |
| MDL号 : | MFCD03453628 | |
| 存储条件： |
Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Propyl pyrazole triol (PPT) is a selective estrogen receptor alpha (ERα) agonist. The relative binding affinity of Propyl pyrazole triol for ERα (ERα: 49%) around 410 times higher compared with estrogen receptor beta (ERβ: 0.12%). The EC50 of Propyl pyrazole triol for the ERα-dependent response is 140 pM in ERα-U2OS(human osteosarcoma)-Luc cells. In the T47D-ERbeta cell line, PPT was unable to suppress cell proliferation at all ratios of ERalpha/ERbeta expression, reflecting its ability to activate only ERalpha and not ERbeta[1]. Moreover, repeated administration of the selective oestrogen receptors (ER)α agonist propyl-pyrazole triol (PPT) results in anxiolytic-like behaviours on the elevated plus maze (EPM) in primiparous (but not nulliparous) female rats. Acute PPT administration significantly modified EPM (elevated plus maze) behaviour as a function of reproductive experience, with nulliparous females tending toward increased anxiety-like behaviours and primiparous females tending toward decreased anxiety-like behaviours[2]. The increased MPO (myeloperoxidase) levels were inhibited with PPT in male pancreas and female lung and with 17β-estradiol in female pancreas[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.59mL 0.52mL 0.26mL |
12.94mL 2.59mL 1.29mL |
25.88mL 5.18mL 2.59mL |
| 参考文献 |
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