N-tert-Butyl-α-phenylnitrone

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Chemical Structure| 3376-24-7 同义名 : N-叔丁基-а-苯基硝酮 ;PBN
CAS号 : 3376-24-7
货号 : A292733
分子式 : C11H15NO
纯度 : 99%
分子量 : 177.24
MDL号 : MFCD00008799
存储条件：

Pure form Inert atmosphere, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 N-tert-Butyl-α-phenylnitrone is a nitrone-derived free radical scavenger capable of forming nitroxide spin adducts. It also impedes COX2 catalytic activity. Moreover, it exhibits potent scavenging of reactive oxygen species (ROS), along with anti-inflammatory, neuroprotective, anti-aging, and anti-diabetic properties, and possesses the ability to penetrate the blood-brain barrier[1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.64mL

1.13mL

0.56mL

28.21mL

5.64mL

2.82mL

56.42mL

11.28mL

5.64mL
参考文献

[1]Zhenggang Zhou, et al. PBN Protects NP Cells From AAPH-induced Degenerative Changes by Inhibiting the ERK1/2 Pathway. Connect Tissue Res. 2020 Mar 30;1-10.

[2]Lei Zhao, et al. Reactive Oxygen Species Contribute to Lipopolysaccharide-Induced Teratogenesis in Mice. Toxicol Sci. 2008 May;103(1):149-57.

[3]Y Kotake, et al. Inhibition of NF-kappaB, iNOS mRNA, COX2 mRNA, and COX Catalytic Activity by phenyl-N-tert-butylnitrone (PBN). Biochim Biophys Acta. 1998 Nov 19;1448(1):77-84.

[4]R A Floyd. Antioxidants, Oxidative Stress, and Degenerative Neurological Disorders. Proc Soc Exp Biol Med. 1999 Dec;222(3):236-45.