PTACH

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Chemical Structure| 848354-66-5 同义名 : NCH-51
CAS号 : 848354-66-5
货号 : A292392
分子式 : C20H26N2O2S2
纯度 : 99%
分子量 : 390.56
MDL号 : MFCD08705329
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PTACH is a SAHA-based inhibitor of human HDAC. PTACH exerts potent growth inhibition against various human cancer cells, with EC50 values ranging from 1 to 10 μM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.56mL

0.51mL

0.26mL

12.80mL

2.56mL

1.28mL

25.60mL

5.12mL

2.56mL
参考文献

[1]Zismanov V, Drucker L, et al. ER homeostasis and motility of NSCLC cell lines can be therapeutically targeted with combined Hsp90 and HDAC inhibitors. Pulm Pharmacol Ther. 2013 Jun;26(3):388-94.

[2]Suzuki T, Nagano Y, et al. Novel inhibitors of human histone deacetylases: design, synthesis, enzyme inhibition, and cancer cell growth inhibition of SAHA-based non-hydroxamates. J Med Chem. 2005 Feb 24;48(4):1019-32.