同义名 :	-
	CAS号 :	2543-94-4
	货号 :	A292146
	分子式 :	C17H16O5
	纯度 :	98%
	分子量 :	300.31
	MDL号 :	MFCD00022251
	存储条件：	Pure form Sealed in dry, 2-8°C In solvent -20°C:3-6个月-80°C:12个月
	溶解度 :	-
	动物实验配方：

生物活性

描述

Phellopterin, a natural product isolated and purified from the roots of Saposhnikovia divaricata, is a partial agonist of the central benzodiazepine receptors in vitro, shows cytotoxic effect on RAW264.7 cell at the concentration from 40 to 400 μM, and reduces TNF-alpha-induced VCAM-1 expression through regulation of the Akt and PKC pathway, which contributes to inhibit the adhesion of monocytes to endothelium.

实验方案
	1mg	5mg	10mg
1 mM 5 mM 10 mM	3.33mL 0.67mL 0.33mL	16.65mL 3.33mL 1.66mL	33.30mL 6.66mL 3.33mL

参考文献

[1]Zhao AH, Yang XB, et al. Biotransformation products of phellopterin by rat liver microsomes and the inhibition on NO production in LPS-activated RAW264.7 cells. J Asian Nat Prod Res. 2012;14(10):956-65. [2]Nizamutdinova IT, Jeong JJ, et al. Hesperidin, hesperidin methyl chalone and phellopterin from Poncirus trifoliata (Rutaceae) differentially regulate the expression of adhesion molecules in tumor necrosis factor-alpha-stimulated human umbilical vein endothelial cells. Int Immunopharmacol. 2008 May;8(5):670-8.