Quercetin

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Chemical Structure| 117-39-5 同义名 : Sophoretin; C.I. 75720; Xanthaurine.; Quertine; Quercetol; Quercetine; NSC 9219; NCI-C60106; Meletin; Kvercetin; NSC 9221
CAS号 : 117-39-5
货号 : A292006
分子式 : C15H10O7
纯度 : 97%
分子量 : 302.24
MDL号 : MFCD00006828
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：

2% DMSO+30% PEG 300+2% Tween 80+water 6 mg/mL

生物活性
靶点

  • Src

  • Src

  • p110β

    PI3Kβ, IC50:5.4 μM

  • p110δ

    PI3Kδ, IC50:3.0 μM
描述 Quercetin, recognized for its presence in various dietary sources as a natural flavonoid, serves dual roles both as a stimulator of recombinant SIRT1 and as an inhibitor of PI3K, exhibiting IC50 values between 2.4 and 5.4 μM across different PI3K isoforms[1]. Quercetin GMP, which is Quercetin produced under Good Manufacturing Practice (GMP) guidelines, serves as an auxiliary reagent in cell therapy manufacturing, leveraging its status as a flavonoid antioxidant, PI3K inhibitor, and SIRT1 activator[1].[2].[3].[4].[5].[6].
细胞研究
细胞系 浓度 检测类型 检测时间 活性说明 数据源
HEK293 FS cells Function assay Inhibition of NOX4 expressed in HEK293 FS cells assessed as H2O2 production by H2O2/Tyr/LPO assay, IC50=0.68 μM 20731357
HT22 cells Function assay Inhibition of glutamate-induced oxytosis of mouse hippocampal HT22 cells, EC50=2.98 μM 16392814
HT22 cells Function assay Neuroprotective activity in mouse HT22 cells assessed as protection against glutamate-induced oxidative damage after 24 hrs by MTT assay, EC50=3.13 μM 24602904
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.31mL

0.66mL

0.33mL

16.54mL

3.31mL

1.65mL

33.09mL

6.62mL

3.31mL
参考文献

[1]Leyre Navarro-Núñez, et al. Effect of quercetin on platelet spreading on collagen and fibrinogen and on multiple platelet kinases. Fitoterapia. 2010 Mar;81(2):75-80.

[2]Yu XB, et al. Inhibitory effects of protein kinase C inhibitors on tumor necrosis factor induced bovine pulmonary artery endothelial cell injuries. Yao Xue Xue Bao. 1996;31(3):176-81.

[3]Yang F, et al. Combination of Quercetin and 2-Methoxyestradiol Enhances Inhibition of Human Prostate Cancer LNCaP and PC-3 Cells Xenograft Tumor Growth. PLoS One. 2015 May 26;10(5):e0128277.

[4]Woo JT, et al. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9.

[5]Kim YJ, et al. Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells. Biochem Pharmacol. 2006 Nov 15;72(10):1268-78.

[6]Pang XG, et al. Quercetin Stimulates Bone Marrow Mesenchymal Stem Cell Differentiation through an Estrogen Receptor-Mediated Pathway. Biomed Res Int. 2018 Mar 15;2018:4178021.