AG-1478 HCl

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Chemical Structure| 170449-18-0 同义名 : -
CAS号 : 170449-18-0
货号 : A288298
分子式 : C16H15Cl2N3O2
纯度 : 97%
分子量 : 352.22
MDL号 : MFCD06804597
存储条件：

Pure form Inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 AG-1478 hydrochloride (Tyrphostin AG-1478 hydrochloride) is a selective inhibitor of EGFR tyrosine kinase with an IC50 of 3 nM. AG-1478 hydrochloride exhibits antiviral effects against HCV and encephalomyocarditis virus (EMCV)[1][2][3][4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.84mL

0.57mL

0.28mL

14.20mL

2.84mL

1.42mL

28.39mL

5.68mL

2.84mL
参考文献

[1]Bojko A, et al. The effect of tyrphostins AG494 and AG1478 on the autocrine growth regulation of A549 and DU145 cells. Folia Histochem Cytobiol. 2012 Jul 5;50(2):186-95.

[2]Li W, et al. EGFR Inhibition Blocks Palmitic Acid-induced inflammation in cardiomyocytes and Prevents Hyperlipidemia-induced Cardiac Injury in Mice. Sci Rep. 2016 Apr 18;6:24580.

[3]Akhtar S, et al. Cationic Polyamidoamine Dendrimers as Modulators of EGFR Signaling In Vitro and In Vivo. PLoS One. 2015 Jul 13;10(7):e0132215.

[4]Dorobantu CM, et al. Tyrphostin AG1478 Inhibits Encephalomyocarditis Virus and Hepatitis C Virus by Targeting Phosphatidylinositol 4-Kinase IIIα. Antimicrob Agents Chemother. 2016 Sep 23;60(10):6402-6.