Amitraz

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Chemical Structure| 33089-61-1 同义名 : BTS-27419; NSC 324552; U 36059; Ovasyn; Taktic; Mitaban
CAS号 : 33089-61-1
货号 : A279484
分子式 : C19H23N3
纯度 : 98%
分子量 : 293.41
MDL号 : MFCD00069396
存储条件:

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 : -
动物实验配方:
生物活性
描述 Amitraz is a member of formamidine family of pesticides used as a veterinary ectoparasiticide (acaricide) for dogs and livestock, and as an agricultural insecticide for fruit crops[3]. Bee survival decreased in the 46 mg/L amitraz and 25 mg/L coumaphos treatments but not in any fluvalinate treatment. Furthermore, the developmental rate decreased in individuals treated with 46 mg/L amitraz[4]. Moreover, polymorphisms in the RmβAOR gene( β-adrenergic octopamine receptor gene) are likely to confer resistance to amitraz[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.41mL

0.68mL

0.34mL

17.04mL

3.41mL

1.70mL

34.08mL

6.82mL

3.41mL

参考文献

[1]del Pino J, Moyano-Cires PV, et al. Molecular mechanisms of amitraz mammalian toxicity: a comprehensive review of existing data. Chem Res Toxicol. 2015 Jun 15;28(6):1073-94.

[2]Pekmezci D, Pekmezci GZ, et al. Efficacy of amitraz plus inactivated parapoxvirus ovis in the treatment of canine generalised demodicosis. Vet Rec. 2014 May 31;174(22):556.

[3]Dhooria S, Agarwal R. Amitraz, an underrecognized poison: A systematic review. Indian J Med Res. 2016 Sep;144(3):348-358. doi: 10.4103/0971-5916.198723. PMID: 28139533; PMCID: PMC5320840.

[4]Dai P, Jack CJ, Mortensen AN, Bustamante TA, Ellis JD. Chronic toxicity of amitraz, coumaphos and fluvalinate to Apis mellifera L. larvae reared in vitro. Sci Rep. 2018 Apr 4;8(1):5635. doi: 10.1038/s41598-018-24045-3. PMID: 29618776; PMCID: PMC5884784.

[5]Corley SW, Jonsson NN, Piper EK, Cutullé C, Stear MJ, Seddon JM. Mutation in the RmβAOR gene is associated with amitraz resistance in the cattle tick Rhipicephalus microplus. Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16772-7. doi: 10.1073/pnas.1309072110. Epub 2013 Sep 30. PMID: 24082133; PMCID: PMC3801038.