NSC697923

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Chemical Structure| 343351-67-7 同义名 : -
CAS号 : 343351-67-7
货号 : A274860
分子式 : C11H9NO5S
纯度 : 97%
分子量 : 267.26
MDL号 : MFCD01925132
存储条件：

Pure form Sealed in dry, store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • E2 conjugating
描述 NSC697923 is a potent inhibitor of UBE2N (ubiquitin-conjugating enzyme E2 N, Ubc13), inducing neuroblastoma (NB) cell death by promoting nuclear importation of p53 in p53 wild-type NB cells. It also induces cell death in p53 mutant NB cells through activation of the JNK-mediated apoptotic pathway and inhibits DNA damage and NF-κB signaling, exhibiting antitumor activity [1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.74mL

0.75mL

0.37mL

18.71mL

3.74mL

1.87mL

37.42mL

7.48mL

3.74mL
参考文献

[1]Cheng J, et al. A small-molecule inhibitor of UBE2N induces neuroblastoma cell death via activation of p53 and JNK pathways. Cell Death Dis. 2014;5(2):e1079. Published 2014 Feb 20.

[2]Hodge CD, et al. Covalent Inhibition of Ubc13 Affects Ubiquitin Signaling and Reveals Active Site Elements Important for Targeting. ACS Chem Biol. 2015;10(7):1718-1728.