GSK484 HCl
产品说明书
 |
同义名 : | GSK484 (hydrochloride); GSK484 hydrochloride |
| CAS号 : | 1652591-81-5 | |
| 货号 : | A268467 | |
| 分子式 : | C27H32ClN5O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 510.03 | |
| MDL号 : | MFCD30343874 | |
| 存储条件： |
Pure form Inert atmosphere, 2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | GSK484 HCl exhibits strong affinity for PAD4 in its low-calcium state, with IC50s of 50 nM without calcium and 250 nM with 2 mM calcium. It also concentration-dependently inhibits PAD4's citrullination of the BAEE substrate in the presence of 0.2 mM calcium, as shown by an ammonia release assay[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
1.96mL 0.39mL 0.20mL |
9.80mL 1.96mL 0.98mL |
19.61mL 3.92mL 1.96mL |
