Nitromide

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Chemical Structure| 121-81-3 同义名 : 硝米特 ;3,5-Dinitrobenzamide
CAS号 : 121-81-3
货号 : A267902
分子式 : C7H5N3O5
纯度 : 98+%
分子量 : 211.13
MDL号 : MFCD00007985
存储条件：

Pure form Sealed in dry, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Nitroxide-enhanced MRI noninvasively quantifies tissue oxidative stress as one component of a multiparametric preclinical MRI examination[3]. Nitroxides can mediate the dispersal of Gram-positive biofilms and that dual-acting biofilm eradication antibiotics may provide broad-spectrum therapies for the treatment of biofilm-related infections[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.74mL

0.95mL

0.47mL

23.68mL

4.74mL

2.37mL

47.36mL

9.47mL

4.74mL
参考文献

[1]Facchini V, Griffiths LA. Metabolism of nitromide in the rat. II. Sites of nitro-reduction. Xenobiotica. 1980 Apr;10(4):299-305.

[2]Facchini V, Griffiths LA. The metabolic fate of nitromide in the rat. I. Metabolism and excretion. Xenobiotica. 1980 Apr;10(4):289-97.

[3]Shah SA, Cui SX, Waters CD, Sano S, Wang Y, Doviak H, Leor J, Walsh K, French BA, Epstein FH. Nitroxide-enhanced MRI of cardiovascular oxidative stress. NMR Biomed. 2020 Sep;33(9):e4359

[4]Verderosa AD, Dhouib R, Fairfull-Smith KE, Totsika M. Nitroxide Functionalized Antibiotics Are Promising Eradication Agents against Staphylococcus aureus Biofilms. Antimicrob Agents Chemother. 2019 Dec 20;64(1):e01685-19