Acetylcholine chloride

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Chemical Structure| 60-31-1 同义名 : ACh chloride; Acetylcholine (chloride); ACh
CAS号 : 60-31-1
货号 : A2668144
分子式 : C7H16ClNO2
纯度 : 99% (TLC)
分子量 : 181.66
MDL号 : MFCD00011698
存储条件：

Pure form Keep in dark place, inert atmosphere, room temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 60 mg/mL(330.29 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 100 mg/mL(550.48 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Acetylcholine chloride (ACh chloride), functioning as a neurotransmitter, acts as a potent cholinergic agonist. It modulates the activity of dopaminergic (DAergic) neurons by stimulating nicotinic acetylcholine receptors (nAChRs)[1].[2]. In vitro studies show that Acetylcholine chloride also inhibits p53 mutant peptide aggregation[5].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.50mL

1.10mL

0.55mL

27.52mL

5.50mL

2.75mL

55.05mL

11.01mL

5.50mL
参考文献

[1]Prashant Tiwari, et al. Basic and modern concepts on cholinergic receptor: A review. Asian Pac J Trop Dis. 2013 Oct;3(5): 413-420.

[2]A Young, et al. Diarrhoea of famine and malnutrition--investigations using a rat model. 2--Ileal hypersecretion induced by starvation. Gut. 1990 Feb;31(2):162-9.

[3]Xia Lei, et al. Effects of acetylcholine chloride on intracellular calcium concentration of cultured sweat gland epithelial cells. Arch Dermatol Res. 2008 Aug;300(7):335-41.

[4]P F Zabrodskii, et al. Effect of acetylcholine on mortality of mice from sepsis and proinflammatory cytokine production. Bull Exp Biol Med. 2011 Jan;150(3):340-2.

[5]Zhaolin Chen, et al. Inhibition of p53 Mutant Peptide Aggregation In Vitro by Cationic Osmolyte Acetylcholine Chloride. Protein Pept Lett. 2017;24(4):353-357.